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Receptor Information

>8i16 Chain A (length=639) Species: 1410628 (Lachnospiraceae bacterium ND2006) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VSPRPRPRYREERTLVRKLLPRPGQSKQEFRENVKKLRKAFLQFNADVSG
VCQWAIQFRPRYGKPAEPTETFWKFFLEPETSLPPNDSRSPEFRRLQAFE
AAAGINGAAALDDPAFTNELRDSILAVASRPKTKEAQRLFSRLKDYQPAH
RMILAKVAAEWIESRYRRAHQNWERNYEEWKKEKQEWEQNHPELTPEIRE
AFNQIFQQLEVKEKRVRICPAARLLQNKDNCQYAGKNKHSVLCNQFNEFK
KNHLQGKAIKFFYKDAEKYLRCGLQSLKPNVQGPFREDWNKYLRYMNLKE
ETLRGKNGGRLPHCKNLGQECEFNPHTALCKQYQQQLSSRPDLVQHDELY
RKWRREYWREPRKPVFRYPSVKRHSIAKIFGENYFQADFKNSVVGLRLDS
MPAGQYLEFAFAPWPRNYRPQPGETEISSVHLHFVGTRPRIGFRFRVPHK
RSRFDCTQEELDELRSRTFPRKAQDQKFLEAARKRLLETFPGNAEQELRL
LAVALGTDSARAAFFIGKTFQQAFPLKIVKIEKLYTVHTARMIRDWARLN
ARQIIQLAEENQVDLIVLESLRGFRPPGYENLDQEKKRRVAFFAHGRIRR
KVTEKAVERGMRVVTVPYLASSVDENAARVLGRVFWGEI

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8i16 Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8i16 Structural transitions upon guide RNA binding and their importance in Cas12g-mediated RNA cleavage.
Resolution	2.24 Å
Binding residue (original residue number in PDB)	H248 C252 C323 C330
Binding residue (residue number reindexed from 1)	H239 C243 C314 C321
Annotation score	4

Enzyme Commision number

	Molecular Function
GO:0003677	DNA binding
GO:0046872	metal ion binding

PDB	RCSB:8i16, PDBe:8i16, PDBj:8i16
PDBsum	8i16
PubMed	37729124
UniProt	A0A7C2YU39

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Structure of PDB 8i16 Chain A Binding Site BS02