Structure of PDB 8hz4 Chain A Binding Site BS02

Receptor Information
>8hz4 Chain A (length=456) Species: 324602 (Chloroflexus aurantiacus J-10-fl) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFRTILVANRGEIALRVMRACRELGLRCVAVYSEADRDAPHVAYADDAFL
IGPPSPAESYLNIDAIIRAAKATGAEAIHPGYGFLAENASFVRAVTAAGL
IFIGPPAEAMERMGGKTAARREATAAGVPVVPGVLEPVTDAAEVRRLGKE
FGYPIAIKAVGGRGLRVVRSPEEVDEAFAAARREAEVAFKNGELYVEKYL
DDPRHIEIQVLADRYGNAVALGERDCSVQRRHQKLIEECPSPALTPELRA
EMGAAAVRLAKAVGYVSAGTLEFLFQDGRYYFLEMNTRIQVEHTVTEMVY
GIDLVAAQIRIAQGEKLWFKQEDVVPRGHAIECRINAEDPLHNFRPALGT
IGEYHEPVGFGVRVDSGVRAYYTVPSHYDSLLAKLITWGSDRQEAIARMR
RALAEYRIEGVTTIIPFHQAALEHPVFTAGAATVNFIPRHPELFSRAAEL
TPPTAA
Ligand information
Ligand IDBCT
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)(O)[O-]
CACTVS 3.341OC([O-])=O
ACDLabs 10.04[O-]C(=O)O
FormulaC H O3
NameBICARBONATE ION
ChEMBL
DrugBank
ZINC
PDB chain8hz4 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8hz4 The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R291 Q293 E295
Binding residue
(residue number reindexed from 1)		R288 Q290 E292
Annotation score5
Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8hz4, PDBe:8hz4, PDBj:8hz4
PDBsum8hz4
PubMed38572988
UniProtA9W9X0

[Back to BioLiP]