Structure of PDB 8ho8 Chain A Binding Site BS02

Receptor Information
>8ho8 Chain A (length=809) Species: 1515 (Acetivibrio thermocellus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFGFFDDANKEYVITVPRTPYPWINYLGTENFFSLISNTAGGYCFYRDAR
LRRITRYRYNNVPIDMGGRYFYIYDNGDFWSPGWSPVKRELESYECRHGL
GYTKIAGKRNGIKAEVTFFVPLNYNGEVQKLILKNEGQDKKKITLFSFIE
FCLWNAYDDMTNFQRNFSTGEVEIEGSVIYHKTEYRERRNHYAFYSVNAK
ISGFDSDRDSFIGLYNGFDAPQAVVNGKSNNSVADGWAPIASHSIEIELN
PGEQKEYVFIIGYVENKDEEKWESKGVINKKKAYEMIEQFNTVEKVDKAF
EELKSYWNALLSKYFLESHDEKLNRMVNIWNQYQCMVTFNMSRSASYFES
GIGRGMGFRDSNQDLLGFVHQIPERARERLLDLAATQLEDGSAYHQYQPL
TKKGNNEIGSNFNDDPLWLILATAAYIKETGDYSILKEQVPFNNDPSKAD
TMFEHLTRSFYHVVNNLGPHGLPLIGRADWNDCLNLNCFSTVPDESFQTT
TSKDGKVAESVMIAGMFVFIGKDYVKLCEYMGLEEEARKAQQHIDAMKEA
ILKYGYDGEWFLRAYDDFGRKVGSKENEEGKIFIESQGFCVMAEIGLEDG
KALKALDSVKKYLDTPYGLVLQNPAFTRYYIEYGEISTYPPGYKENAGIF
CHNNAWIICAETVVGRGDMAFDYYRKIAPAYIEDVSDIHKLEPYVYAQMV
AGKDAKRHGEAKNSWLTGTAAWNFVAISQWILGVKPDYDGLKIDPCIPKA
WDGYKVTRYFRGSTYEITVKNPNHVSKGVAKITVDGNEISGNILPVFNDG
KTHKVEVIL
Ligand information
Ligand IDBGC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.7.6C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-glucopyranose;
beta-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL1614854
DrugBankDB02379
ZINCZINC000003833800
PDB chain8ho8 Chain C Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ho8 The cryo-EM structure of cellobiose phosphorylase from Clostridium thermocellum in complex with cellobiose
Resolution2.24 Å
Binding residue
(original residue number in PDB)		D361 W481 D483 E646
Binding residue
(residue number reindexed from 1)		D360 W480 D482 E645
Annotation score5
Enzymatic activity
Enzyme Commision number 2.4.1.20: cellobiose phosphorylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016757 glycosyltransferase activity
GO:0030246 carbohydrate binding
GO:0047738 cellobiose phosphorylase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0030245 cellulose catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ho8, PDBe:8ho8, PDBj:8ho8
PDBsum8ho8
PubMed
UniProtQ8VP44

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