Structure of PDB 8hnw Chain A Binding Site BS02

Receptor Information
>8hnw Chain A (length=809) Species: 729 (Haemophilus parainfluenzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ILGLDLGIASVGWAVVEIDEKENPLRLIDVGVRTFEGESLALSRRLARSA
RRLTQRRVARLKKAKRLLKSENILLSTDERLPHQVWQLRVEGLDHKLERQ
EWAAVLLHLIKHRGYLSQRKNESKELGALLSGVDNNHKLLQQATYRSPAE
LAVKKFEVEEGHIRNQQGAYTHTFSRLDLLAEMELLFSRQQHFGNPFASE
KLLENLTALLMWQKPALSGEAILKMLGKFEDEYKAAKNTYSAERFVWITK
LNNLRIQENGLERALNDNERLALMEQPYDKNRLFYSQVRSILKLSDIFKG
LRIETKAVLMEMKAYHQIRKVLEGNNLKAEWAELKANPTLLDEIGTAFSL
YKTDEDISAYLAGKLSQPVLNALLENLSFDKFIQLSLKALYKLLPLMQQG
LRYDEACREIYFLPQIPADEIRNPVVLRTLTQARKVINGVVRLYGSPARI
HIETRNLNDTRYVARFLCNFIADNMHLVFASNGQITALLNDRHHALDAVV
VACSTVAMQQKITRFLHFPTPWQFFKQEVEIRIFSDNPKLELENRLPDRP
QANHEFVQPLFVSRMPTRKMTGQGHMETVKSAKRLNEGISVIKMPLTKLK
LKDLELMVNREREKDLYDTLKARLEAFNDDPAKAFAEPFIKKGGAIVKSV
RVEQIQKSGVLVREGNGVADNASMVRVDVFTKGGKYFLVPIYTWQVAKGI
LPNKAATQYKDEEDWEVMDNSATFKFSLHPNDLVKLVTKKKTILGYFNGL
NRATGNIDIKEHDLDKSKGKQGIFEGVGIKLALSFEKYQVDELGKNIRLC
KPSKRQPVR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hnw AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.
Resolution3.41 Å
Binding residue
(original residue number in PDB)		Q133 R134 K135 G146 A147 L148 L149 Y189 L236 M244 L245 N274 R276 K383 D411 D435 R664 Y665 R668 Q732 M821 E822 T823 K847 Y954 N1001 G1021 V1022 G1023 I1024 K1025 L1026
Binding residue
(residue number reindexed from 1)		Q118 R119 K120 G127 A128 L129 L130 Y170 L217 M225 L226 N253 R255 K352 D380 D404 R461 Y462 R465 Q510 M576 E577 T578 K602 Y709 N756 G776 V777 G778 I779 K780 L781
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8hnw, PDBe:8hnw, PDBj:8hnw
PDBsum8hnw
PubMed37494395
UniProtF0ET08

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