Structure of PDB 8hmn Chain A Binding Site BS02

Receptor Information

>8hmn Chain A (length=312) Species: 1590 (Lactiplantibacillus plantarum)

IGINGFGRIGRLAFRRILELIEVVAINDLTSPALLAHLLKYDSTHGTLNA
DVSATDDSIVVNGKNYRVYAEPQAQNVLECTGFYTSKAKSQAHKRVLISA
PAGSDLKTIVYNVNDDILTADDRIVSAGSCTTNCLAPLAFFENKEFGIKV
GTMTTIHAYTSTQMLLDGPVRGGNFRAARAAGVNTIPHSTGAAKALGLVI
PELNGKLQGHAQRVGVVDGSLTELVAILDKKVTADEVNAAIKKHTEGNES
FGYNDDEIVSSDVIGTTFGSIFDPTQTEVTSDGDNQLVKTVAWYDNEYGF
TCQMVRTLLKFA

Ligand information

• Ligand ID: ART
• InChI: InChI=1S/AsH3O4/c2-1(3,4)5/h(H3,2,3,4,5)/p-3
• InChIKey: DJHGAFSJWGLOIV-UHFFFAOYSA-K
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-][As](=O)([O-])[O-]
  ACDLabs 10.04
  CACTVS 3.341: [O-][As]([O-])([O-])=O
• Formula: As O4
• Name: ARSENATE
• PDB chain: 8hmn Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8hmn Crystal structure of GAPDH complexed with arsenate from Lactiplantibacillus plantarum
• Resolution: 2.16 Å
• Binding residue (original residue number in PDB): T186 T188 R239
• Binding residue (residue number reindexed from 1): T160 T162 R213
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8hmn, PDBe:8hmn, PDBj:8hmn
• PDBsum: 8hmn
• UniProt: Q88YH6