Structure of PDB 8hkk Chain A Binding Site BS02

Receptor Information
>8hkk Chain A (length=899) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSS
SEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFR
VSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRS
AMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTV
GYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKQTEKHVV
LCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLW
SQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRA
WAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPA
TSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREY
EGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYI
NITKEENSAFIFKQEEKRKIAPVLELAVEYVKGYPPNSPYIGSSPTLCHL
LPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIV
PLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSL
LQCGIIYADNLVVVDKEAEEDYMADAKTIVNVQTMFRLFPSLSITTELTH
PSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSIS
MLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIRTYG
RLFQKLCSSSAEIPIGIYRTESHVFAAAEWISQQRLSLYRRSERQELSEL
VKNRMKHLGLPTTGYDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPLA
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain8hkk Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hkk Structural basis of human Slo2.2 channel gating and modulation.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		R780 L781 K783 G784 N788 Y790 Y796
Binding residue
(residue number reindexed from 1)		R561 L562 K564 G565 N569 Y571 Y577
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006813 potassium ion transport
Cellular Component
GO:0016020 membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hkk, PDBe:8hkk, PDBj:8hkk
PDBsum8hkk
PubMed37494189
UniProtQ5JUK3|KCNT1_HUMAN Potassium channel subfamily T member 1 (Gene Name=KCNT1)

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