Structure of PDB 8hir Chain A Binding Site BS02

Receptor Information
>8hir Chain A (length=918) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRV
LLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVA
IISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNL
FIPVFLNCWLAKHALENMINDFHRSAMFNQVLILFCTLLCLVFTGTCGIQ
HLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALV
VLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFL
NEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQ
DLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQ
ILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQ
EGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKK
YGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFVEYVK
GYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNK
LIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAIC
CFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKT
IVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERE
NGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTT
PGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHAAEWI
SQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYDHQNTLSYVLINPPPD
TRLEPSDIVYLIRSDPLA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hir Chain A Residue 1307 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hir Structural basis of human Slo2.2 channel gating and modulation.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		C778 C785 H787
Binding residue
(residue number reindexed from 1)		C577 C584 H586
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006813 potassium ion transport
Cellular Component
GO:0016020 membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hir, PDBe:8hir, PDBj:8hir
PDBsum8hir
PubMed37494189
UniProtQ5JUK3|KCNT1_HUMAN Potassium channel subfamily T member 1 (Gene Name=KCNT1)

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