Structure of PDB 8hip Chain A Binding Site BS02

Receptor Information
>8hip Chain A (length=647) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVLVFEISSKMKMIEKKLEANTVHVLRLELDQSFILDLTKVAAEIVDSSK
YSKEDGVILEVTVSNGRDSFLLKLPTVYPNLKLYTDGKLLNPLVEQDFHF
HQNLIVTVQSRLNADIDYRLHVTHLDRAQYDFLKFKTGQTTKTLSNQKLT
FVKPIGFFLNCSEQNISQFHVTLYSEDDICANLITVPANESIYDRSVISD
KTHNRRVLSFTKRADIFFTETEISMFKSFRIFVFIAPDDSGCSTNTSRKS
FNEKKKISFEFKKLENQSYAVPTALMMIFLTTPCLLFLPIVINIIKNSRS
LHGQMLQYPVAIILPVLMHTAIEFHKWTTSTMANRDEMCFHNHACARPLG
ELRAWNNIITNIGYTLYGAIFIVLSICRRGSHVFGTYECTLLDVTIGVFM
VLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQWFVRHESPSPAYT
NILLVGVVSLNFLISAFSKTSYVRFIIAVIHVIVVGSICLAKERSLGSEK
LKTRFFIMAFSMGNFAAIVMYLTLSAFHLNQIATYCFIINCIMYLMYYGC
MKVLHSERITSKAKLCGALSLLAWAVAGFFFFQDDTDWTRSAAASRALNK
PCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLINTRKTSINIF
Ligand information
Ligand ID6OU
InChIInChI=1S/C39H76NO8P/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-39(42)48-37(36-47-49(43,44)46-34-33-40)35-45-38(41)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h17-18,37H,3-16,19-36,40H2,1-2H3,(H,43,44)/b18-17-/t37-/m1/s1
InChIKeyFHQVHHIBKUMWTI-OTMQOFQLSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P](O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
OpenEye OEToolkits 2.0.6CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCC/C=C\CCCCCCCC
CACTVS 3.385CCCCCCCCCCCCCCCC(=O)OC[CH](CO[P](O)(=O)OCCN)OC(=O)CCCCCCCC=CCCCCCCCC
OpenEye OEToolkits 2.0.6CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCC=CCCCCCCCC
FormulaC39 H76 N O8 P
Name[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
ChEMBL
DrugBank
ZINCZINC000008437520
PDB chain8hip Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hip Structure of dsRNA transporter at 2.77 Angstroms resolution.
Resolution2.77 Å
Binding residue
(original residue number in PDB)		G585 L589 I609 V613 A620 R623
Binding residue
(residue number reindexed from 1)		G456 L460 I480 V484 A491 R494
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8hip, PDBe:8hip, PDBj:8hip
PDBsum8hip
PubMed38664565
UniProtQ9GZC8|SID1_CAEEL Systemic RNA interference defective protein 1 (Gene Name=sid-1)

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