Structure of PDB 8he5 Chain A Binding Site BS02

Receptor Information
>8he5 Chain A (length=1412) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APVSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVFKH
ISPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLT
HKLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQ
ALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQ
VGVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRI
DLRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVM
PYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVS
PQSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQP
AILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVM
FGVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFS
IGIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRES
FEGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSA
CVGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEF
FFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDI
IQFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVI
EYAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRR
IIQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQ
NATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGE
MVGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIA
LDIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFS
QSPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLI
IRCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEY
KNEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSL
YKEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALM
RCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEK
LLTSLPADYAPT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8he5 Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome.
Resolution6.95 Å
Binding residue
(original residue number in PDB)		A252 M253 E255 R321 D415 Y418 R447 D484 D486
Binding residue
(residue number reindexed from 1)		A238 M239 E241 R307 D401 Y404 R433 D470 D472
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8he5, PDBe:8he5, PDBj:8he5
PDBsum8he5
PubMed37120012
UniProtC4R4Y0

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