Structure of PDB 8hac Chain A Binding Site BS02

Receptor Information

>8hac Chain A (length=325) Species: 556484 (Phaeodactylum tricornutum CCAP 1055/1)

LPDPSLKNIIDQTTLQWVFVGGKGGVGKTTTSCCLGVQLAKSRTKVLLVS
TDPAHNLSDAFCQKIGREPTPIHGFDNLCAMEIDNDVFGQMFNDLQNSIP
GIDEAMSFSELMKQVQQLDFDVVVFDTAPTGHTLRLLSFPTILEKAFAKV
WELKDRFGGLIGQATALMSGGNNPAAAQEQLLGKLEETRAVINKVNQAFQ
DPTKTTFVCVCIPEFLSIYETERLVQELSKYGIDSHNIVVNQVLFPEKDA
EELSAWYEANGATLPKEAREICSKLLARKRMQDKYIGQCFDLYGDDFHVV
LMPLLDYEVRGVEKLKTFSELLVDP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8hac Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8hac A novel dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo
• Resolution: 2.32 Å
• Binding residue (original residue number in PDB): T34 D57 N61
• Binding residue (residue number reindexed from 1): T29 D52 N56
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.-.-

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
• GO:0045048 protein insertion into ER membrane

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0043529 GET complex

External links

• PDB: RCSB:8hac, PDBe:8hac, PDBj:8hac
• PDBsum: 8hac
• PubMed: 38867239
• UniProt: B7G933