Structure of PDB 8h5y Chain A Binding Site BS02
Receptor Information
>8h5y Chain A (length=564) Species:
83333
(Escherichia coli K-12) [
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MIFTLRPYQQEAVDATLNHFRRHKTPAVIVLPTGAGKSLVIAELARLARG
RVLVLAHVKELVAQNHAKYQALGLEADIFAAGGKVVFGSVQSVARNLDAF
QGEFSLLIVDECHRIGDDEESQYQQILTHLTKVNPHLRLLGLTATPFRLG
KGWIYQFHYHGMVRGDEKALFRDCIYELPLRYMIKHGYLTPPERLDMPVV
QYDFSRLQAQSNGLFSEADLNRELKKQQRITPHIISQIMEFAATRKGVMI
FAATVEHAKEIVGLLPAEDAALITGDTPGAERDVLIENFKAQRFRYLVNV
AVLTTGFDAPHVDLIAILRPTESVSLYQQIVGRGLRLAPGKTDCLILDYA
GNPHDLYAPEVGTPKGKSDNVPVQVFCPACGFANTFWGKTTADGTLIEHF
GRRCQGWFEDDDGHREQCDFRFRFKNCQCNAENDIAARRCDTVLVDPDDM
LKAALRLKDALVLRCSGMSLQHGHDEKGEWLKITYYDEDGADVSERFRLQ
TPAQRTAFEQLFIRPHTRTPGIPLRWITAADILAQQALLRHPDFVVARMK
GQYWQVREKVFDYE
Ligand information
Ligand ID
ADP
InChI
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey
XTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341
Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04
O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
Formula
C10 H15 N5 O10 P2
Name
ADENOSINE-5'-DIPHOSPHATE
ChEMBL
CHEMBL14830
DrugBank
DB16833
ZINC
ZINC000012360703
PDB chain
8h5y Chain A Residue 602 [
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Receptor-Ligand Complex Structure
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PDB
8h5y
Biochemical and Structural Analyses Shed Light on the Mechanisms of RadD DNA Binding and Its ATPase from Escherichia coli.
Resolution
2.7001 Å
Binding residue
(original residue number in PDB)
T4 R6 Q9 T33 G34 G36 K37 L39 K68 R343
Binding residue
(residue number reindexed from 1)
T4 R6 Q9 T33 G34 G36 K37 L39 K68 R336
Annotation score
5
Enzymatic activity
Enzyme Commision number
3.6.4.12
: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003697
single-stranded DNA binding
GO:0004386
helicase activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0008270
zinc ion binding
GO:0016787
hydrolase activity
GO:0016887
ATP hydrolysis activity
GO:0046872
metal ion binding
Biological Process
GO:0006281
DNA repair
GO:0006301
postreplication repair
GO:0006302
double-strand break repair
GO:0006412
translation
GO:0009410
response to xenobiotic stimulus
GO:0010212
response to ionizing radiation
GO:0051301
cell division
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:8h5y
,
PDBe:8h5y
,
PDBj:8h5y
PDBsum
8h5y
PubMed
36614183
UniProt
P33919
|RADD_ECOLI Putative DNA repair helicase RadD (Gene Name=radD)
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