Structure of PDB 8gs2 Chain A Binding Site BS02

Receptor Information
>8gs2 Chain A (length=1452) Species: 45657 (Desulfonema ishimotonii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTTTMKISIEFLEPFRMTKWQESTRRNKNNKEFVRGQAFARWHRNKKDNT
KGRPYITGTLLRSAVIRSAENLLTLSDGKISEKTCCPGKFDTEDKDRLLQ
LRQRSTLRWTDKNPCPDNAETYCPFCELLGRSFRIHFGNLSLPGKPDFDG
PKAIGSQRVLNRVDFKSGKAHDFFKAYEVDHTRFPRFEGEITIDNKVSAE
ARKLLCDSLKFTDRLCGALCVIRFDLAEKTAEQIISILDDNKKTEYTRLL
ADAIRSLRRSSKLVAGLPKDHDGKDDHYLWDIGVTIRQILTTSADTKELK
NAGKWREFCEKLGEALYLKSKDMSGGLKITRRILGDAEFHGKPDRLEKSR
SVSIGSVLKETVVCGELVAKTPFFFGAIDEDAKQTDLQVLLTPDNKYRLP
RSAVRGILRRDLQTYFDSPCNAELGGRPCMCKTCRIMRGITVMDARSEYN
APPEIRHRTRINPFTGTVAEGALFNMEVAPEGIVFPFQLRYRGSEDGLPD
ALKTVLKWWAEGQAFMSGAASTGKGRFRMENAKYETLDLSDENQRNDYLK
NWGWRDEKGLEELKKRLNSGLPEPGNYRDPKWHEINVSIEMASPFINGDP
IRAAVDKRGTDVVTFVKYKAEGEEAKPVCAYKAESFRGVIRSAVARIHME
DGVPLTELTHSDCECLLCQIFGSEYEAGKIRFEDLVFESDPEPVTFDHVA
IDRFTGGAADKKKFDDSPLPGSPARPLMLKGSFWIRRDVLEDEEYCKALG
KALADVNNGLYPLGGKSAIGYGQVKSLGIKGDDKRISRLMNVAVPEKPKT
DAEVRIEAEKVYYPHYFVEPHKKVEREEKPCGHQKFHEGRLTGKIRCKLI
TKTPLIVPDTSNDDFFYHKSYAFFRLHKQIMIPGSELRGMVSSVYETVTN
SCFRIFDETKRLSWRMDAQDFLPGRVTADGKHIQKFSETARVPFYDKTQK
HFDILDEQEIAGEKPVRMWVKRFRYQKAFQEIPENDPDGWECKEGYLHVV
GPSKVEFSDKKGDVINNFQGTLPSVPNDWKTIRTNDFKNRKRKNEPVFCC
EDDKGNYYTMAKYCETFFFDLKENEEYEIPEKARIKYKELLRVYNNNPQA
VPESVFQSRVARENVEKLKSGDLVYFKHNEKYVEDIVPVRISRTVDDRMI
GKRMSADLRPCHGDWVEDGDLSALNAYPEKRLLLRHPKGLCPACRLFGTG
SYKGRVRFGFASLENDPEWLIPGKNPGDPFHGGPVMLSLLERPRPTWSIP
GSDNKFKVPGRKFYVHHHAWKTIKDGNHPTTGKAIEQSPNNRTVEALAGG
NSFSFEIAFENLKEWELGLLIHSLQLEKGLAHKLGMAKSMGFGSVEIDVE
SVRLRKDWKQWRNGNSEIPNWLGKGFAKLKEWFRDELDFIENLKKLLWFP
EGDQAPRVCYPMLRKKDDPNGNSGYEELKDGEFKKEDRQKKLTTPWTPWA
SS
Ligand information
>8gs2 Chain D (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uacccaugucgaagacaacaaag
.......................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gs2 RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		Y281 R283 H306 Y313 Y360 K364 T373 D429 G514 L516 F517 E717 D753 K754 K755 K756 F757 A981 E1007 R1125 Q1127 K1155 E1157 S1159 D1160 P1249 Q1250 L1391 R1393 R1443 R1565
Binding residue
(residue number reindexed from 1)		Y246 R248 H271 Y278 Y317 K321 T330 D386 G471 L473 F474 E674 D710 K711 K712 K713 F714 A918 E938 R974 Q976 K1004 E1006 S1008 D1009 P1098 Q1099 L1240 R1242 R1292 R1414
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Biological Process
External links
PDB RCSB:8gs2, PDBe:8gs2, PDBj:8gs2
PDBsum8gs2
PubMed36423304
UniProtA0A401FT36

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