Structure of PDB 8gnk Chain A Binding Site BS02
Receptor Information
>8gnk Chain A (length=525) Species:
10116
(Rattus norvegicus) [
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RFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFL
LECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIY
YLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQ
MTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYI
MLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLG
LGSLIALGSYNSYHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVT
KRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFC
TVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKL
FDYYSASGMSLLFLVFFECVSISWFYGVNRFSEDIRDMIGFPPCIWWKLC
WSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIP
GYMAYMFLTLKGSLKQRLQVMIQPS
Ligand information
Ligand ID
NA
InChI
InChI=1S/Na/q+1
InChIKey
FKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0
[Na+]
Formula
Na
Name
SODIUM ION
ChEMBL
DrugBank
DB14516
ZINC
PDB chain
8gnk Chain A Residue 604 [
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Receptor-Ligand Complex Structure
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PDB
8gnk
Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.
Resolution
3.1 Å
Binding residue
(original residue number in PDB)
G65 S295
Binding residue
(residue number reindexed from 1)
G16 S246
Annotation score
5
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005283
amino acid:sodium symporter activity
GO:0005332
gamma-aminobutyric acid:sodium:chloride symporter activity
GO:0005515
protein binding
GO:0015185
gamma-aminobutyric acid transmembrane transporter activity
GO:0015293
symporter activity
GO:0015378
sodium:chloride symporter activity
GO:0042802
identical protein binding
GO:0046872
metal ion binding
Biological Process
GO:0003333
amino acid transmembrane transport
GO:0006836
neurotransmitter transport
GO:0006865
amino acid transport
GO:0007612
learning
GO:0007613
memory
GO:0008306
associative learning
GO:0009636
response to toxic substance
GO:0009744
response to sucrose
GO:0010288
response to lead ion
GO:0014054
positive regulation of gamma-aminobutyric acid secretion
GO:0014070
response to organic cyclic compound
GO:0014074
response to purine-containing compound
GO:0032229
negative regulation of synaptic transmission, GABAergic
GO:0032355
response to estradiol
GO:0035725
sodium ion transmembrane transport
GO:0042220
response to cocaine
GO:0050808
synapse organization
GO:0051592
response to calcium ion
GO:0051939
gamma-aminobutyric acid import
GO:0098658
inorganic anion import across plasma membrane
GO:0098719
sodium ion import across plasma membrane
GO:0098810
neurotransmitter reuptake
GO:1902476
chloride transmembrane transport
GO:1904313
response to methamphetamine hydrochloride
Cellular Component
GO:0005886
plasma membrane
GO:0009986
cell surface
GO:0016020
membrane
GO:0030424
axon
GO:0042734
presynaptic membrane
GO:0042995
cell projection
GO:0043025
neuronal cell body
GO:0045202
synapse
GO:0045211
postsynaptic membrane
GO:0098793
presynapse
GO:0098982
GABA-ergic synapse
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:8gnk
,
PDBe:8gnk
,
PDBj:8gnk
PDBsum
8gnk
PubMed
37400654
UniProt
P23978
|SC6A1_RAT Sodium- and chloride-dependent GABA transporter 1 (Gene Name=Slc6a1)
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