Structure of PDB 8gap Chain A Binding Site BS02

Receptor Information
>8gap Chain A (length=1012) Species: 5911 (Tetrahymena thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFL
TTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQI
GTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTK
VEQNGYLQVAGVCLNQYFSENQYIYPEIQRSQIFYCNHMGREPGVFKSSF
FNYSEPQTIIKKTLLKEYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNY
LLKKFCKLPENYQSLKSQVKQIVQSENKANQQSCENLFNSLYDTEISYKQ
ITNFLRQIIQNCVPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICF
MDVFDVEWFVDLKNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRYN
FYITEKHKEGSQIFYYRKPIWKLVSKLTIVKLEEENLEKVEEKLIPEDSF
QKYPQGKLRIIPKKGSFRPIMTFLRKDKQKNIKLNLNQILMDSQLVFRNL
KDMLGQKIGYSVFDNKQISEKFAQFIEKWKNKGRPQLYYVTLDIKKCYDS
IDQMKLLNFFNQSDLIQDTYFINKYLLFQRNKRPLLQIMDNINFPYYFNL
KERQIAYSLYDDDDQILQKGFKEIQSDDRPFIVINQDKPRCITKDIIHNH
LKHISQYNVISFNKVKFRQKRGIPQGLNISGVLCSFYFGKLEEEYTQFLK
NAEQVNGSINLLMRLTDDYLFISDSQQNALNLIVQLQNCANNNGFMFNDQ
KITTNFQFPQEDYNLEHFKISVQNECQWIGKSIDMNTLEIKSIQKQTQQE
INQTINVAISIKNLKSQLKNKLRSLFLNQLIDYFNPNINSFEGLCRQLYH
HSKATVMKFYPFMTKLFQIDLKKSKQYSVQYGKENTNENFLKDILYYTVE
DVCKILCYLQFEDEINSNIKEIFKNLYSWIMWDIIVSYLKKKKQFKGYLN
KLLQKIRKSRFFYLKEGCKSLQLILSQQKYQLNKKELEAIEFIDLNNLIQ
DIKTLIPKISAK
Ligand information
>8gap Chain B (length=159) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auacccgcuuaauucauucagaucuguaauagaacugucauucaacccca
aaaaucuagugcugauauaaccuucaccaauuagguucaaauaaguggua
augcgggacaaaagacuaucgacauuugauacacuauuuaucaauggaug
ucuuauuuu
...<<<<<..........<<<.<<<<...>>>>.>>>.............
..................<<<<<..((((.((>>>>>.....)).)))).
..>>>>>.....<<<<.<<<..<<<.<<<<<.......>>>>>>>>>>>>
>>>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gap Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		S179 Y221 H234 M235 R237 F242 K243 S244 N324 Y325 L327 K328 K329 K332 L333 Y337 Q338 L420 D421 C424 D427 V428 F429 Q444 K445 R446 K447 S450 R453 R473 R492 K532 R534 L549 R550 K576 R658 M687 Y694 N697 G774 I909 K910 K913 S914 K917 I967 K971 S972 K973 K990 Y994 Y995 K1040 K1041 Q1052 K1056 F1059 F1060 Y1061
Binding residue
(residue number reindexed from 1)		S169 Y175 H188 M189 R191 F196 K197 S198 N249 Y250 L252 K253 K254 K257 L258 Y262 Q263 L345 D346 C349 D352 V353 F354 Q369 K370 R371 K372 S375 R378 R398 R417 K457 R459 L474 R475 K501 R583 M589 Y596 N599 G676 I811 K812 K815 S816 K819 I869 K873 S874 K875 K892 Y896 Y897 K942 K943 Q954 K958 F961 F962 Y963
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0042162 telomeric DNA binding
GO:0046872 metal ion binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0007004 telomere maintenance via telomerase
Cellular Component
GO:0000333 telomerase catalytic core complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005697 telomerase holoenzyme complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gap, PDBe:8gap, PDBj:8gap
PDBsum8gap
PubMed37330293
UniProtO77448|TERT_TETTS Telomerase reverse transcriptase (Gene Name=TERT)

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