Structure of PDB 8g9o Chain A Binding Site BS02

Receptor Information

>8g9o Chain A (length=868) Species: 8355 (Xenopus laevis)

QVFRFYWLDAYEDQYSQPGVVYLFGKVWIESADAYVSCCVSVKNIERTVY
LLPRENRVQLSTGKDTGAPVSMMHVYQEFNEAVAEKYKIMKFKSKKVDKD
YAFEIPDVPASSEYLEVRYSADSPQLPQDLKGETFSHVFGTNTSSLELFL
LSRKIKGPSWLEIKSPQLSSQPMSWCKVEAVVTRPDQVSVVKDLAPPPVV
VLSLSMKTVQNAKTHQNEIVAIAALVHHTFPLDKAPPQPPFQTHFCVLSK
LNDCIFPYDYNEAVKQKNANIEIALTERTLLGFFLAKIHKIDPDVIVGHD
IYGFDLEVLLQRINSCKVPFWSKIGRLRRSVMPKLGGRSGFAERNAACGR
IICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENIRNAYNDSVHL
LYMLENTWIDAKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERN
EYLLLHAFTENNFIVPDKPVAAYAGGLVLEPKVGFYDKFILLLDFNSLYP
SIIQEYNICFTTVHREADEIPELPHSDLEMGILPREIRKLVERRRHVKQL
MKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTH
QGREILLHTKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSE
INKSYKLLEIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLD
IVRRDWCELAKQAGNYVISQILSDQPRDSIVENIQKKLTEIGENVTNGTV
PITQYEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTISYV
ICQDGSNLSASQRAYAQEQLQKQENLSIDTQYYLSQQVHPVVARICEPID
GIDSALIAMWLGLDPSQF

Ligand information

>8g9o Chain D (length=20)

ggauacugcgtgaacttagc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8g9o A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
• Resolution: 4.4 Å
• Binding residue (original residue number in PDB): D998 R1077 R1078 K1133 A1134 T1136 Y1142 K1145 H1150
• Binding residue (residue number reindexed from 1): D624 R703 R704 K759 A760 T762 Y768 K771 H776

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006260 DNA replication
• GO:1902975 mitotic DNA replication initiation

External links

• PDB: RCSB:8g9o, PDBe:8g9o, PDBj:8g9o
• PDBsum: 8g9o
• PubMed: 38491139
• UniProt: Q9DE46|DPOLA_XENLA DNA polymerase alpha catalytic subunit (Gene Name=pola1)