Structure of PDB 8g9f Chain A Binding Site BS02

Receptor Information
>8g9f Chain A (length=1063) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVFRFYWLDAYEDQYSQPGVVYLFGKVWIESADAYVSCCVSVKNIERTVY
LLPRENRVQLSTGKDTGAPVSMMHVYQEFNEAVAEKYKIMKFKSKKVDKD
YAFEIPDVPASSEYLEVRYSADSPQLPQDLKGETFSHVFGTNTSSLELFL
LSRKIKGPSWLEIKSPQLSSQPMSWCKVEAVVTRPDQVSVVKDLAPPPVV
VLSLSMKTVQNAKTHQNEIVAIAALVHHTFPLDKAPPQPPFQTHFCVLSK
LNDCIFPYDYNEAVKQKNANIEIALTERTLLGFFLAKIHKIDPDVIVGHD
IYGFDLEVLLQRINSCKVPFWSKIGRLRRSVMPKLGGRSGFAERNAACGR
IICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENIRNAYNDSVHL
LYMLENTWIDAKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERN
EYLLLHAFTENNFIVPDKPVGLVLEPKVGFYDKFILLLDFNSLYPSIIQE
YNICFTTVHREIPELPHSDLEMGILPREIRKLVERRRHVKQLMKQPDLNP
DLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTHQGREILLH
TKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSEINKSYKLL
EIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCE
LAKQAGNYVISQILSDQPRDSIVENIQKKLTEIGENVTNGTVPITQYEIN
KALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTISYVICQDGSNL
SASQRAYAQEQLQKQENLSIDTQYYLSQQVHPVVARICEPIDGIDSALIA
MWLGLDPSQFRDEENDALLGGPSQLTDEEKYRDCERFKFFCPKCGTENIY
DNVFDGSGLQIEPGLKRCSKPECDASPLDYVIQVHNKLLLDIRRYIKKYY
SGWLVCEEKTCQNRTRRLPLSFSRNGPICQACSKATLRSEYPEKALYTQL
CFYRFIFDWDYALEKVVSEQERGHLKKKLFQESENQYKKLKSTVDQVLSR
SGYSEVNLSKLFQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8g9f Chain A Residue 1501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g9f A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C1345 C1350 C1368 C1371
Binding residue
(residue number reindexed from 1)		C956 C961 C979 C982
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:1902975 mitotic DNA replication initiation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8g9f, PDBe:8g9f, PDBj:8g9f
PDBsum8g9f
PubMed38491139
UniProtQ9DE46|DPOLA_XENLA DNA polymerase alpha catalytic subunit (Gene Name=pola1)

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