Structure of PDB 8g5m Chain A Binding Site BS02

Receptor Information
>8g5m Chain A (length=932) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLP
PLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRY
GPEGEAVPVAIPEERALVFAVAVCLAEGTCPTLAVAISPSAWYSWCSQRL
VEERYSWTSQLSPADLIPLEVRDWQEQLVVGHNVSFDRAHIREQYLIQGS
RMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHARRGPAISSWDWLDISS
VNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWA
THEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTY
EELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQPMDQE
DLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCP
RLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLNDVDI
PGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEI
NKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQV
VTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQ
ELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISRE
HAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRW
YRWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSR
VNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDR
YRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMD
CKTPSNPTGMERRYGIPQGEALDIYQIIELTK
Ligand information
Receptor-Ligand Complex Structure
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PDB8g5m Structural basis for DNA proofreading.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		F307 S310 R337 R338 L558 M596 Y614 F961
Binding residue
(residue number reindexed from 1)		F220 S223 R235 R236 L430 M468 Y486 F717
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000262 mitochondrial chromosome
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005760 gamma DNA polymerase complex
GO:0032991 protein-containing complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g5m, PDBe:8g5m, PDBj:8g5m
PDBsum8g5m
PubMed38151585
UniProtP54098|DPOG1_HUMAN DNA polymerase subunit gamma-1 (Gene Name=POLG)

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