Structure of PDB 8g10 Chain A Binding Site BS02
Receptor Information
>8g10 Chain A (length=351) Species:
10090
(Mus musculus) [
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TGPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQ
LNTGSYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFGNPLS
HFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIR
NPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVP
KFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLE
QLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFF
LECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
L
Ligand information
>8g10 Chain F (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8g10
The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Resolution
2.47 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 N196 Y200 Y201 K372
Binding residue
(residue number reindexed from 1)
R17 S21 A24 N52 Y56 Y57 K216
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8g10
,
PDBe:8g10
,
PDBj:8g10
PDBsum
8g10
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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