Structure of PDB 8fua Chain A Binding Site BS02

Receptor Information

>8fua Chain A (length=423) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPK
FVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLAS
PHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLAC
GYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCW
AISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTG
TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQV
VNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIE
PLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKI
EALQRHENESVYKASLNLIEKYF

Ligand information

>8fua Chain C (length=9) Species: 928303 (Hendra virus horse/Australia/Hendra/1994) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SGKRKKIRT

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fua Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	S105 W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238 A269 D270
Binding residue (residue number reindexed from 1)	S32 W69 N73 S76 G77 T82 Q108 W111 N115 D119 W158 R165 A196 D197

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8fua, PDBe:8fua, PDBj:8fua
PDBsum	8fua
PubMed	37376602
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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