Structure of PDB 8fta Chain A Binding Site BS02

Receptor Information
>8fta Chain A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIK
EPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANS
IKKIFYMKKAEIEHHE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8fta Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fta Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with compound 16
Resolution1.78 Å
Binding residue
(original residue number in PDB)		H290 E291
Binding residue
(residue number reindexed from 1)		H115 E116
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8fta, PDBe:8fta, PDBj:8fta
PDBsum8fta
PubMed
UniProtQ86U86|PB1_HUMAN Protein polybromo-1 (Gene Name=PBRM1)

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