Structure of PDB 8fr3 Chain A Binding Site BS02

Receptor Information
>8fr3 Chain A (length=385) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKA
RGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAA
TDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELL
SQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAID
KPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTG
VEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESE
VYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIK
MVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVL
Ligand information
Ligand IDY7C
InChIInChI=1S/C11H12ClN5O/c1-2-6-17-11(14-15-16-17)13-10(18)8-4-3-5-9(12)7-8/h3-5,7H,2,6H2,1H3,(H,13,14,16,18)
InChIKeyIBRCUOMIAFDQTM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CCCn1c(nnn1)NC(=O)c2cccc(c2)Cl
CACTVS 3.385CCCn1nnnc1NC(=O)c2cccc(Cl)c2
ACDLabs 12.01CCCn1nnnc1NC(=O)c1cccc(Cl)c1
FormulaC11 H12 Cl N5 O
Name3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide
ChEMBL
DrugBank
ZINCZINC000000578793
PDB chain8fr3 Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fr3 Antibiotic that inhibits trans -translation blocks binding of EF-Tu to tmRNA but not to tRNA.
Resolution2.23 Å
Binding residue
(original residue number in PDB)		G317 R318 E378 V383
Binding residue
(residue number reindexed from 1)		G310 R311 E371 V376
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0032045 guanyl-nucleotide exchange factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fr3, PDBe:8fr3, PDBj:8fr3
PDBsum8fr3
PubMed37681945
UniProtP0CE47|EFTU1_ECOLI Elongation factor Tu 1 (Gene Name=tufA)

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