Structure of PDB 8fhr Chain A Binding Site BS02

Receptor Information

>8fhr Chain A (length=475) Species: 7955,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVG
VAMHTVGFAATVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGME
WESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLV
PDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIF
WTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTEC
TQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAP
IISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVI
MFLLTWWAALIAIGVVLFLLLYVIY

Ligand information

Ligand ID

InChI

InChI=1S/Na/q+1

InChIKey

FKNQFGJONOIPTF-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Na+]

Formula

Name

SODIUM ION

PDB chain

8fhr Chain A Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fhr Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	L148 W151 A464 S467 S468
Binding residue (residue number reindexed from 1)	L18 W21 A334 S337 S338
Annotation score	5

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0015377	chloride:monoatomic cation symporter activity
GO:0022857	transmembrane transporter activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:8fhr, PDBe:8fhr, PDBj:8fhr
PDBsum	8fhr
PubMed	36792826
UniProt	A0A0G2KTI4\|S12A2_DANRE Solute carrier family 12 member 2 (Gene Name=slc12a2); P55017\|S12A3_HUMAN Solute carrier family 12 member 3 (Gene Name=SLC12A3)

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