Structure of PDB 8fhf Chain A Binding Site BS02

Receptor Information
>8fhf Chain A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL
KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKF
EFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALE
LQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPL
LQEIYKDL
Ligand information
Ligand IDKNA
InChIInChI=1S/C9H18O2/c1-2-3-4-5-6-7-8-9(10)11/h2-8H2,1H3,(H,10,11)
InChIKeyFBUKVWPVBMHYJY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)CCCCCCCC
OpenEye OEToolkits 1.7.2CCCCCCCCC(=O)O
CACTVS 3.370CCCCCCCCC(O)=O
FormulaC9 H18 O2
Namenonanoic acid
ChEMBLCHEMBL108436
DrugBank
ZINCZINC000001529234
PDB chain8fhf Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fhf Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437
Resolution2.1 Å
Binding residue
(original residue number in PDB)		C285 R288 I341 S342 M348
Binding residue
(residue number reindexed from 1)		C67 R70 I123 S124 M130
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fhf, PDBe:8fhf, PDBj:8fhf
PDBsum8fhf
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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