Structure of PDB 8f8l Chain A Binding Site BS02
Receptor Information
>8f8l Chain A (length=344) Species:
1773
(Mycobacterium tuberculosis) [
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MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRLRPLFA
YWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQ
LRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPD
AQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTV
SRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDDVLGVFGDPAVTGK
PSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSIGTRLTDAQVRELR
TVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGLSELA
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
8f8l Chain A Residue 403 [
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Receptor-Ligand Complex Structure
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PDB
8f8l
The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
D84 D88
Binding residue
(residue number reindexed from 1)
D84 D88
Annotation score
1
Enzymatic activity
Enzyme Commision number
2.5.1.1
: dimethylallyltranstransferase.
2.5.1.10
: (2E,6E)-farnesyl diphosphate synthase.
Gene Ontology
Molecular Function
GO:0004161
dimethylallyltranstransferase activity
GO:0004337
geranyltranstransferase activity
GO:0004659
prenyltransferase activity
GO:0016740
transferase activity
GO:0046872
metal ion binding
Biological Process
GO:0006629
lipid metabolic process
GO:0008299
isoprenoid biosynthetic process
GO:0033384
geranyl diphosphate biosynthetic process
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:8f8l
,
PDBe:8f8l
,
PDBj:8f8l
PDBsum
8f8l
PubMed
UniProt
O53507
|GFPPS_MYCTU (2E,6E)-farnesyl diphosphate synthase (Gene Name=idsA2)
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