Structure of PDB 8f69 Chain A Binding Site BS02

Receptor Information
>8f69 Chain A (length=412) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VAREALVDLCRRRHFLSGTPQQLSTAALLSGCHARFGPLGVELRKNLASQ
WWSSMVVFREQVFAVDSLHQEPGSSQPRDSAFRLVSPESIREILQDREPS
KEQLVAFLENLLKTSGKLRATLLHGALEHYVNCLDLVNRKLPFGLAQIGV
CFHPVTRVGEKTEASLVWFTPTRTSSQWLDFWLRHRLLWWRKFAMSPSNF
SSADCQDELGRKGSKLYYSFPWGKEPIETLWNLGDQELLHTYPGNVSTIQ
GRDGRKNVVPCVLSVSGDVDLGTLAYLYDSFQLAENSFARKKSLQRKVLK
LHPCLAPIKVALDVGKGPTVELRQVCQGLLNELLENGISVWPGYSETVHS
SLEQLHSKYDEMSVLFSVLVTETTLENGLIQLRSRDTTMKEMMHISKLRD
FLVKYLASASNV
Ligand information
Receptor-Ligand Complex Structure
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PDB8f69 Structure-specific roles for PolG2-DNA complexes in maintenance and replication of mitochondrial DNA.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R299 R302
Binding residue
(residue number reindexed from 1)		R252 R255
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0030337 DNA polymerase processivity factor activity
GO:0042802 identical protein binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0007005 mitochondrion organization
GO:0032042 mitochondrial DNA metabolic process
GO:0071897 DNA biosynthetic process
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005760 gamma DNA polymerase complex
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8f69, PDBe:8f69, PDBj:8f69
PDBsum8f69
PubMed37592734
UniProtQ9QZM2|DPOG2_MOUSE DNA polymerase subunit gamma-2 (Gene Name=Polg2)

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