Structure of PDB 8exa Chain A Binding Site BS02

Receptor Information
>8exa Chain A (length=341) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRNKAFVVRLYPNAAQTELINRTLGSARFVYNHFLARRIAAYKESGKGLT
YGQTSSELTLLKQAEETSWLSEVDKFALQNSLKNLETAYKNFFRTVKQSG
KKVGFPRFRKKRTGESYRTQFTNNNIQIGEGRLKLPKLGWVKTKGQQDIQ
GKILNVTVRRIHEGHYEASVLCEVEIPYLPAAPKFAAGVDVGIKDFAIVT
DGVRFKHEQNPKYYRSTLKRLRKAQQTLSRRKKGSARYGKAKTKLARIHK
RIVNKRQDFLHKLTTSLVREYEIIGTEHLKPDNMRKNRRLALSISDAGWG
EFIRQLEYKAAWYGRLVSKVSPDRDENAALNIRREALVAAG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8exa TnpB structure reveals minimal functional core of Cas12 nuclease family.
Resolution3.14 Å
Binding residue
(original residue number in PDB)		Y43 K48 T60 K63 K76 F77 Q80 F94 F106 K135 P137 K138
Binding residue
(residue number reindexed from 1)		Y42 K47 T59 K62 K75 F76 Q79 F93 F105 K134 P136 K137
Enzymatic activity
Enzyme Commision number 3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006310 DNA recombination
GO:0032196 transposition

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Molecular Function
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Biological Process
External links
PDB RCSB:8exa, PDBe:8exa, PDBj:8exa
PDBsum8exa
PubMed37020015
UniProtQ7DF80|DRA2B_DEIRA RNA-guided DNA endonuclease TnpB (Gene Name=tnpB)

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