Structure of PDB 8evf Chain A Binding Site BS02

Receptor Information
>8evf Chain A (length=411) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSY
EARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQ
QKEGMRKQGLFQWLDSLLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAG
ISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGAS
VIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQL
PKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQ
LVVSIRVQSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLT
MLFLCATKFSA
Ligand information
Receptor-Ligand Complex Structure
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PDB8evf The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta.
Resolution2.87 Å
Binding residue
(original residue number in PDB)		S113 E116 S257 G259 G260 K261 L262 R382 R383
Binding residue
(residue number reindexed from 1)		S111 E114 S242 G244 G245 K246 L247 R362 R363
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8evf, PDBe:8evf, PDBj:8evf
PDBsum8evf
PubMed37468099
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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