Structure of PDB 8esv Chain A Binding Site BS02

Receptor Information

>8esv Chain A (length=446) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRN
ISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYV
FTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQN
YGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIM
YARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQ
GEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAF
KSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQC
AGSICEKYGLEECTCDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTI
TLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENI

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8esv Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8esv Structural basis for membrane-proximal proteolysis of substrates by ADAM10.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	H383 H387 H393
Binding residue (residue number reindexed from 1)	H166 H170 H176
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.24.81: ADAM10 endopeptidase.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8esv, PDBe:8esv, PDBj:8esv
PDBsum	8esv
PubMed	37516108
UniProt	O14672\|ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (Gene Name=ADAM10)

[Back to BioLiP]