Structure of PDB 8eij Chain A Binding Site BS02

Receptor Information

>8eij Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLE
LFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAA
EAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLY
PAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVG
TVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGL
YEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFL
ECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNR
IAKLKKVQTITTKSLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGR
GARQKLLGRSWSVPVIRHLFAPLKDYFACE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8eij Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8eij Cryo-EM structure of human DNMT3B homo-trimer
Resolution	3.34 Å
Binding residue (original residue number in PDB)	C438 C455 C458
Binding residue (residue number reindexed from 1)	C24 C41 C44
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity
GO:0009008	DNA-methyltransferase activity

	Biological Process
GO:0010468	regulation of gene expression

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Molecular Function

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Biological Process

External links

PDB	RCSB:8eij, PDBe:8eij, PDBj:8eij
PDBsum	8eij
PubMed	37941146
UniProt	Q9UBC3\|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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