Structure of PDB 8eho Chain A Binding Site BS02

Receptor Information
>8eho Chain A (length=164) Species: 28344 (Porcine reproductive and respiratory syndrome virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPTCGITTYSPPTDGSCGWHVLAAIMNRMINGDFTSPLTQYNRPEDDWAS
DYDLVQAIQCLQLPATVVRNRACPNAKYLIKLNGVHWEVEVRSGMAPRSL
PRECVVGVCSEGCVAPPYPADGLPKRALEALASAYRLPSDCVSSGIADFL
ANPPPQEFWTLDKM
Ligand information
Ligand ID3CN
InChIInChI=1S/C3H9N/c1-2-3-4/h2-4H2,1H3
InChIKeyWGYKZJWCGVVSQN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04NCCC
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CCCN
FormulaC3 H9 N
Name3-AMINOPROPANE
ChEMBLCHEMBL14409
DrugBank
ZINCZINC000016052656
PDB chain8eho Chain B Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8eho Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis
Resolution2.85 Å
Binding residue
(original residue number in PDB)		G427 C429 W460 V497
Binding residue
(residue number reindexed from 1)		G15 C17 W48 V85
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Biological Process
GO:0016032 viral process
GO:0019082 viral protein processing

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Biological Process
External links
PDB RCSB:8eho, PDBe:8eho, PDBj:8eho
PDBsum8eho
PubMed38096325
UniProtW0NX70

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