Structure of PDB 8egw Chain A Binding Site BS02

Receptor Information

>8egw Chain A (length=317) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ADPQAGSLDLQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVG
TDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDH
APAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGE
TFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQA
LLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGA
VTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGA
HPELGSAFVTVHVRDAN

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

8egw Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8egw Structure of the planar cell polarity cadherins Fat4 and Dachsous1.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	N249 H251 D281 D283 N287 D336
Binding residue (residue number reindexed from 1)	N210 H212 D242 D244 N248 D297
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:8egw, PDBe:8egw, PDBj:8egw
PDBsum	8egw
PubMed	36797229
UniProt	Q96JQ0\|PCD16_HUMAN Protocadherin-16 (Gene Name=DCHS1)

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