Structure of PDB 8efc Chain A Binding Site BS02

Receptor Information
>8efc Chain A (length=595) Species: 8187 (Lates calcarifer) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFSIIDVASDRRLFNTFIKEWKTKERYSLALACEKREHDSDGLVLIGLSV
CWGARDSYYISLQQVSERLGQVRSCLSRPGGVVVTYDIIQVYKTLVLSCG
ISLAGNCEDPKVACWLLDPGSEERTLPNMVTVYCPEELPLLDGLAHCPRV
RAATKSVLVHAVMNHLTGLLEKDSMLDLFRSIEMPSQVCLALLELNGVGF
SVEECERQKHVMQAKLTALESQAYNLAGHSFSLTSIDDIAQVLFLELHLP
QFSTTKDILEKLRPLHPLPGVILEWRRITNALTKVVFPLQREKQYHPTLA
MDRIYPIAQTHTATGRVSFTEPNIQNVPKDFEICMAFSVSMRHAFVPFSG
GMILAADYSQLELRVLAHLSKDQRLLQVLNGGADVFRCIAAEWKGVDPET
VNDSLRQQAKQICYGIIYGMGAKSLGEQMGVEENDAACYIESFKARYKGI
NAFLKETVKNCIKNGYVQTLMGRRRYLPGISNTNTHIKAHAERQAVNTTV
QGSAADIVKLATVNIQKRLRKTYPTAPLSHQHTLRGAFFVLQLHDELIYE
TREEDLIQVAQIVKREMESAVKLYVKLKAKVKVGPSWGNLQDLDL
Ligand information
Receptor-Ligand Complex Structure
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PDB8efc Structural basis of DNA polymerase theta mediated DNA end joining.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		T2321 K2322 R2343 P2394 K2395 R2448
Binding residue
(residue number reindexed from 1)		T255 K256 R277 P328 K329 R342
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8efc, PDBe:8efc, PDBj:8efc
PDBsum8efc
PubMed36583344
UniProtA0A4W6BKE5

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