Structure of PDB 8eey Chain A Binding Site BS02

Receptor Information
>8eey Chain A (length=1544) Species: 45657 (Desulfonema ishimotonii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTTMKISIEFLEPFRMTKWQESTRRNKNNKEFVRGQAFARWHRNKKDNTK
GRPYITGTLLRSAVIRSAENLLTLSDGKISEKTCCPGKFDTEDKDRLLQL
RQRSTLRWTDKNPCPDNAETYCPFCELLGRSWRFRIHFGNLSLPGKPDFD
GPKAIGSQRVLNRVDFKSGKAHDFFKAYEVDHTRFPRFEGEITIDNKVSA
EARKLLCDSLKFTDRLCGALCVIRFNLAEKTAEQIISILDDNKKTEYTRL
LADAIRSLRRSSKLVAGLPKDHDGKDDHYLWDIGKSVTIRQILTTSADTK
ELKNAGKWREFCEKLGEALYLKSKDMSGGLKITRRILGDAEFHGKPDRLE
KSRSVSIGSVLKETVVCGELVAKTPFFFGAIDEDAKQTALQVLLTPDNKY
RLPRSAVRGILRRDLQTYFDSPCNAELGGRPCMCKTCRIMRGITVMDARS
EYNAPPEIRHRTRINPFTGTVAEGALFNMEVAPEGIVFPFQLRYRGSEDG
LPDALKTVLKWWAEGQAFMSGAASTGKGRFRMENAKYETLDLSDENQRND
YLKNWGWRDEKGLEELKKRLNSGLPEPGNYRDPKWHEINVSIEMASPFIN
GDPIRAAVDKRGTAVVTFVKYKAEGEEAKPVCAYKAESFRGVIRSAVARI
HMEDGVPLTELTHSDCECLLCQIFGSEYEAGKIRFEDLVFESDPEPVTFD
HVAIDRFTGGAADKKKFDDSPLPGSPARPLMLKGSFWIRRDVLEDEEYCK
ALGKALADVNNGLYPLGGKSAIGYGQVKSLGIKGDDKRISRLMNVAVPEK
PKTDAEVRIEAEKVYYPHYFVEPHKKVEREEKPCGHQKFHEGRLTGKIRC
KLITKTPLIVPDTSNDDFFRPEYHKSYAFFRLHKQIMIPGSELRGMVSSV
YETVTNSCFRIFDETKRLSWRMDADHQNVLQDFLPGRVTADGKHIQKFSE
TARVPFYDKTQKHFDILDEQEIAGEKPVRMWVKRFIKRLSLVDPAKHPQK
KQDNKWKRRKEGIATFIEQKNGSYYFNVVTNNGCTSFHLWHKPDNFDQEK
LEGIQNGEKLDCWVRDSRYQKAFQEIPENDPDGWECKEGYLHVVGPSKVE
FSDKKGDVINNFQGTLPSVPNDWKTIRTNDFKNRKRKNEPVFCCEDDKGN
YYTMAKYCETFFFDLKENEEYEIPEKARIKYKELLRVYNNNPQAVPESVF
QSRVARENVEKLKSGDLVYFKHNEKYVEDIVPVRISRTVDDRMIGKRMSA
DLRPCHGDWVEDGDLSALNAYPEKRLLLRHPKGLCPACRLFGTGSYKGRV
RFGFASLENDPEWLIPGKNPGDPFHGGPVMLSLLERPRPTWSIPGSDNKF
KVPGRKFYVHHHAWKTIKDGNHPTTGKAIEQSPNNRTVEALAGGNSFSFE
IAFENLKEWELGLLIHSLQLEKGLAHKLGMAKSMGFGSVEIDVESVRLRK
DWKQWRNGNSEIPNWLGKGFAKLKEWFRDELDFIENLKKLLWFPEGDQAP
RVCYPMLRKKDDPNGNSGYEELKDGEFKKEDRQKKLTTPWTPWA
Ligand information
>8eey Chain D (length=28) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uacccaugucgaagacaacaaaguauuu
............................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8eey RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
Resolution2.53 Å
Binding residue
(original residue number in PDB)
K182 Y281 R283 H306 Y313 K364 T373 R375 V511 G514 L516 F517 D705 E717 Y718 D753 K754 K756 F757 D980 H983 Q984 R1125 Q1127 K1155 E1157 S1159 Q1250 L1391 E1392 R1393 N1441 R1443 R1565
Binding residue
(residue number reindexed from 1)
K170 Y247 R249 H272 Y279 K324 T333 R335 V471 G474 L476 F477 D665 E677 Y678 D713 K714 K716 F717 D923 H926 Q927 R1068 Q1070 K1098 E1100 S1102 Q1193 L1334 E1335 R1336 N1384 R1386 R1508
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Biological Process
External links
PDB RCSB:8eey, PDBe:8eey, PDBj:8eey
PDBsum8eey
PubMed36423276
UniProtA0A401FT36

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