Structure of PDB 8ecc Chain A Binding Site BS02
Receptor Information
>8ecc Chain A (length=346) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKGNPLSHFLEG
EVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEI
SVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQG
ETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKK
EFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECL
RTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
>8ecc Chain F (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8ecc
Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA
Resolution
2.44 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 N196 Y200 Y201 K372
Binding residue
(residue number reindexed from 1)
R13 S17 A20 N48 Y52 Y53 K212
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8ecc
,
PDBe:8ecc
,
PDBj:8ecc
PDBsum
8ecc
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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