Structure of PDB 8ebt Chain A Binding Site BS02

Receptor Information
>8ebt Chain A (length=603) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLV
AIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDG
IMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRN
SEGEATETVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINID
LKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRK
RCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAIST
YSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQ
AHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAE
VWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKII
VFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISK
VGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRYNAFFYSLVSQDTQ
EMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLA
ATD
Ligand information
>8ebt Chain M (length=45) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atatcgcacgtctattatcctcagcgcaatcagctgtgactacct
Receptor-Ligand Complex Structure
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PDB8ebt Lesion recognition by XPC, TFIIH and XPA in DNA excision repair.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		K449 M450 R472 E473 K526 K528 H629
Binding residue
(residue number reindexed from 1)		K340 M341 R363 E364 K417 K419 H520
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0006367 transcription initiation at RNA polymerase II promoter

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Molecular Function
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Biological Process
External links
PDB RCSB:8ebt, PDBe:8ebt, PDBj:8ebt
PDBsum8ebt
PubMed37076618
UniProtP19447|ERCC3_HUMAN General transcription and DNA repair factor IIH helicase/translocase subunit XPB (Gene Name=ERCC3)

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