Structure of PDB 8eb0 Chain A Binding Site BS02

Receptor Information
>8eb0 Chain A (length=255) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKLELSCME
GSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFP
ALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRT
SIEEKMTAARIRKCHKCGTGLIKSEGANRMSCRCGAQMCYLCRVSINGYD
HFCQHPRPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTRI
GPPLE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8eb0 Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8eb0 The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family.
Resolution3.03 Å
Binding residue
(original residue number in PDB)		H534 C559 C564
Binding residue
(residue number reindexed from 1)		H23 C48 C53
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8eb0, PDBe:8eb0, PDBj:8eb0
PDBsum8eb0
PubMed36631489
UniProtQ9NWF9|RN216_HUMAN E3 ubiquitin-protein ligase RNF216 (Gene Name=RNF216)

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