BioLiP

>8ear Chain A (length=2389) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRD
CLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNET
ENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAG
NEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPG
CNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE
HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRF
KHLATGHYLAAEVDPDFKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLV
PRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPLKEDKEAFAI
VPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVY
FVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGD
GPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQ
KQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLD
YLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEEEVWLF
WRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQY
LAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQVT
PVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVC
QRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH
VPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQS
PGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPP
LVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRS
IVEKSELWVYKGESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQR
LLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQA
LLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHG
RNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQT
LIQMMRSERDRMDENSPLFMYHIHLVELLAVCTEGKNVYTEIKCNSLLPL
DDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFEN
FLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPFSDQSTTLQ
TRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPV
DLDSQVNNLFLKSSVLAASRDYRNIIERLQDIVSALEDRLRPLVQAELSV
LVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKV
LQTLREMMTKDRGPPLRQLEDHKRGEALRQILVNRYYGNISTSRGEMSLA
EVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSF
FCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKDDLEMSA
VITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCIC
GSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESN
GIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAER
ILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHNIYILAH
QLARHNKELQTMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFP
VPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLR
AQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSG
LLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFN
VCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEF
FYSLLLFDLVYREETLLNVIKSVTRNGRPIILTAALALILVYLFSIVGYL
FFKDDFILEVDRLPNETAEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDV
LRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQK
KEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKD
STEYTGPESYVAEMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKL
ESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPH

Software

SMILES

OpenEye OEToolkits 1.5.0

c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

CACTVS 3.341

Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O

ACDLabs 10.04

O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O

OpenEye OEToolkits 1.5.0

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N

CACTVS 3.341

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O

Molecular Function

GO:0005216

monoatomic ion channel activity

GO:0005220

inositol 1,4,5-trisphosphate-gated calcium channel activity

GO:0005262

calcium channel activity

calcium ion binding

protein binding

ATP binding

intracellularly gated calcium channel activity

GO:0019855

calcium channel inhibitor activity

GO:0019903

protein phosphatase binding

GO:0019904

protein domain specific binding

GO:0035091

phosphatidylinositol binding

GO:0042802

identical protein binding

GO:0044325

transmembrane transporter binding

GO:0044877

protein-containing complex binding

GO:0046872

metal ion binding

GO:0070679

inositol 1,4,5 trisphosphate binding

GO:0098695

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

	Biological Process
GO:0000902	cell morphogenesis
GO:0001666	response to hypoxia
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0006915	apoptotic process
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO:0007338	single fertilization
GO:0009791	post-embryonic development
GO:0010976	positive regulation of neuron projection development
GO:0016358	dendrite development
GO:0019722	calcium-mediated signaling
GO:0032024	positive regulation of insulin secretion
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0036444	calcium import into the mitochondrion
GO:0042045	epithelial fluid transport
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0050849	negative regulation of calcium-mediated signaling
GO:0050882	voluntary musculoskeletal movement
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051289	protein homotetramerization
GO:0051480	regulation of cytosolic calcium ion concentration
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070588	calcium ion transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071456	cellular response to hypoxia
GO:0097421	liver regeneration
GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway
GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration
GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum
GO:1990806	ligand-gated ion channel signaling pathway
GO:2000347	positive regulation of hepatocyte proliferation

Biological Process

GO:0000902

cell morphogenesis

GO:0001666

response to hypoxia

GO:0006811

monoatomic ion transport

GO:0006816

calcium ion transport

GO:0006915

apoptotic process

GO:0007200

phospholipase C-activating G protein-coupled receptor signaling pathway

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO:0007207

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

GO:0007338

single fertilization

GO:0009791

post-embryonic development

GO:0010976

positive regulation of neuron projection development

GO:0016358

dendrite development

GO:0019722

calcium-mediated signaling

GO:0032024

positive regulation of insulin secretion

GO:0032469

endoplasmic reticulum calcium ion homeostasis

GO:0036444

calcium import into the mitochondrion

GO:0042045

epithelial fluid transport

GO:0043065

positive regulation of apoptotic process

GO:0043066

negative regulation of apoptotic process

GO:0050849

negative regulation of calcium-mediated signaling

GO:0050882

voluntary musculoskeletal movement

GO:0051209

release of sequestered calcium ion into cytosol

GO:0051289

protein homotetramerization

GO:0051480

regulation of cytosolic calcium ion concentration

GO:0051928

positive regulation of calcium ion transport

GO:0055085

transmembrane transport

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO:0070588

calcium ion transmembrane transport

GO:0071320

cellular response to cAMP

GO:0071456

cellular response to hypoxia

GO:0097421

liver regeneration

GO:0099105

ion channel modulating, G protein-coupled receptor signaling pathway

GO:0099566

regulation of postsynaptic cytosolic calcium ion concentration

GO:1903514

release of sequestered calcium ion into cytosol by endoplasmic reticulum

GO:1990806

ligand-gated ion channel signaling pathway

GO:2000347

positive regulation of hepatocyte proliferation

	Cellular Component
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005955	calcineurin complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0030425	dendrite
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0030868	smooth endoplasmic reticulum membrane
GO:0031088	platelet dense granule membrane
GO:0031094	platelet dense tubular network
GO:0031410	cytoplasmic vesicle
GO:0032991	protein-containing complex
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0097060	synaptic membrane
GO:0098685	Schaffer collateral - CA1 synapse
GO:0098793	presynapse
GO:0098794	postsynapse
GO:0098982	GABA-ergic synapse

Cellular Component

GO:0005635

nuclear envelope

GO:0005637

nuclear inner membrane

GO:0005730

nucleolus

GO:0005737

cytoplasm

GO:0005783

endoplasmic reticulum

GO:0005789

endoplasmic reticulum membrane

plasma membrane

calcineurin complex

postsynaptic density

membrane

sarcoplasmic reticulum

GO:0030425

dendrite

GO:0030658

transport vesicle membrane

GO:0030667

secretory granule membrane

GO:0030868

smooth endoplasmic reticulum membrane

GO:0031088

platelet dense granule membrane

GO:0031094

platelet dense tubular network

GO:0031410

cytoplasmic vesicle

GO:0032991

protein-containing complex

GO:0043025

neuronal cell body

GO:0045202

synapse

GO:0048471

perinuclear region of cytoplasm

GO:0097060

synaptic membrane

GO:0098685

Schaffer collateral - CA1 synapse

GO:0098793

presynapse

GO:0098794

postsynapse

GO:0098982

GABA-ergic synapse

PDB	RCSB:8ear, PDBe:8ear, PDBj:8ear
PDBsum	8ear
PubMed	36376291
UniProt	P29994\|ITPR1_RAT Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (Gene Name=Itpr1)

Structure of PDB 8ear Chain A Binding Site BS02