Structure of PDB 8eae Chain A Binding Site BS02
Receptor Information
>8eae Chain A (length=356) Species:
10090
(Mus musculus) [
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DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRINPLSH
FLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRN
PEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPK
NAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKL
MKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFD
KLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNG
FPIFDK
Ligand information
>8eae Chain F (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8eae
Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppG(2,5)pI
Resolution
2.56 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 N196 Y200 Y201 K372
Binding residue
(residue number reindexed from 1)
R14 S18 A21 N49 Y53 Y54 K222
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8eae
,
PDBe:8eae
,
PDBj:8eae
PDBsum
8eae
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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