Structure of PDB 8e4l Chain A Binding Site BS02

Receptor Information
>8e4l Chain A (length=898) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLVNFIQANFKDAFGDIQFGKYLRLSCDTDSETLYELLTQHWHLKTPNLV
ISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEV
VRDNTISENIVAIGIAAWGMVSNRDTLFSAQYIMLYILDNNHTHLLLVDN
GCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKA
INTSVKSKIPCVVVEGSGQIADVIASLVEVLTSSMVKEKLVRFLPRTVSR
LPEEEIESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFST
NEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIK
DRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYND
ALLTFVWKLVANFRRSLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCT
LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSNDED
LAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISR
DTKNWKIILCLFIIPWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMD
FHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYF
IAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIM
LQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYL
AMFGQVPSDVDSTTRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGI
VQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCNETLAWE
GVMKENYLVKINTKANDNSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
Ligand information
Ligand IDUL9
InChIInChI=1S/C4H5NS/c1-2-3-5-4-6/h2H,1,3H2
InChIKeyZOJBYZNEUISWFT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		C=CCN=C=S
ACDLabs 12.01C=CC\N=C=S
FormulaC4 H5 N S
Name3-isothiocyanatoprop-1-ene
ChEMBLCHEMBL233248
DrugBank
ZINCZINC000001687017
PDB chain8e4l Chain A Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e4l Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Resolution3.32 Å
Binding residue
(original residue number in PDB)		W798 Q861
Binding residue
(residue number reindexed from 1)		W639 Q702
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0034220 monoatomic ion transmembrane transport
GO:0050955 thermoception
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0044853 plasma membrane raft
GO:0045121 membrane raft

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8e4l, PDBe:8e4l, PDBj:8e4l
PDBsum8e4l
PubMed36227998
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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