Structure of PDB 8e2q Chain A Binding Site BS02
Receptor Information
>8e2q Chain A (length=154) Species:
562
(Escherichia coli) [
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VEFSHEYWMRHALALAKRARDEREVPVGAVLVLNNRVIGEGWNRGIGLHD
PTAHAEIMALRQGGLVMQNYRLYDATLYTTFEPCVMCAGAMIHSRIGRVV
FGVRNAKTGAAGSLMDVLHHPGMNHRVEITEGILADECEALLCRFFRMPR
RVFN
Ligand information
>8e2q Chain F (length=13) [
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gctcggctgcgga
Receptor-Ligand Complex Structure
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PDB
8e2q
Improved cytosine base editors generated from TadA variants.
Resolution
2.34 Å
Binding residue
(original residue number in PDB)
R74 Y76 R98
Binding residue
(residue number reindexed from 1)
R71 Y73 R95
Enzymatic activity
Enzyme Commision number
3.5.4.33
: tRNA(adenine(34)) deaminase.
Gene Ontology
Molecular Function
GO:0003824
catalytic activity
GO:0008251
tRNA-specific adenosine deaminase activity
GO:0008270
zinc ion binding
GO:0016787
hydrolase activity
GO:0042803
protein homodimerization activity
GO:0046872
metal ion binding
GO:0052717
tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100
tRNA wobble adenosine to inosine editing
GO:0006382
adenosine to inosine editing
GO:0008033
tRNA processing
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Molecular Function
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Biological Process
External links
PDB
RCSB:8e2q
,
PDBe:8e2q
,
PDBj:8e2q
PDBsum
8e2q
PubMed
36624149
UniProt
P68398
|TADA_ECOLI tRNA-specific adenosine deaminase (Gene Name=tadA)
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