Structure of PDB 8e24 Chain A Binding Site BS02

Receptor Information
>8e24 Chain A (length=644) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTGFPIK
GCDDTLVVGLAVCWGGRDAYYFSLQKESLDPSLTLKDRMWYLQSCLRKES
DKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLH
SIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNS
MNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIM
QAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNTSKDVLNKLK
AHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTAT
GRITFTEPNIQNVPRDFEIKMPTLADRGMPFSISMRHAFVPFPGGSILAA
DYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLR
QQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTE
TVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAAD
IVKIATVNIQKQLETFHSTFKSHGHREGMLFCPIRGGFFILQLHDELLYE
VAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e24 Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		K2181 N2205 R2241 Q2250 N2251 V2252 P2253 R2254 R2315 H2539
Binding residue
(residue number reindexed from 1)		K293 N316 R352 Q361 N362 V363 P364 R365 R386 H594
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8e24, PDBe:8e24, PDBj:8e24
PDBsum8e24
PubMed36126059
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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