Structure of PDB 8e0f Chain A Binding Site BS02

Receptor Information
>8e0f Chain A (length=384) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKD
AKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYL
NNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILE
EPADRHPNRKARGQLRTKIESGQGTIPVRSNASIQTWDGVLQGERLLTMS
CSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRIS
NIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINAT
TGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAA
KEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSL
Ligand information
>8e0f Chain D (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cguagcuaucagagccccccggcaucgcgagc
................................
Receptor-Ligand Complex Structure
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PDB8e0f ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R348 I456 F457 R474 R477 R481 G487 Q488 I491 R494 R510
Binding residue
(residue number reindexed from 1)		R33 I141 F142 R159 R162 R166 G172 Q173 I176 R179 R195
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:8e0f, PDBe:8e0f, PDBj:8e0f
PDBsum8e0f
PubMed36243986
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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