Structure of PDB 8dvl Chain A Binding Site BS02

Receptor Information

>8dvl Chain A (length=610) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWT
DISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRI
EVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMD
GSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIA
DDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDI
LVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTC
SAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQL
YWIDSRQNMIRKAQEDGSQGFTVVVSEIQPYDLSIDIYSRYIYWTCEATN
VINVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERA
ALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR
IVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIA
QLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVL
LQDELSCGEP

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

8dvl Chain A Residue 1303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8dvl Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	L1150 D1190 I1191
Binding residue (residue number reindexed from 1)	L514 D554 I555
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:8dvl, PDBe:8dvl, PDBj:8dvl
PDBsum	8dvl
PubMed	36893429
UniProt	O75581\|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

[Back to BioLiP]