Structure of PDB 8dr3 Chain A Binding Site BS02

Receptor Information

>8dr3 Chain A (length=643) Species: 4932 (Saccharomyces cerevisiae)

NITAQDVLDKIPSLDLSFPEGKPNCLLGLTIVFTGVLPTLERGASEALAK
RYGARVTKSISSKTSVVVLGDEAGPKKLEKIKQLKIKAIDEEGFKQLIAG
MPAEGGDGEAAEKARRKLEEQHNIATKEAELLVKKEEERSKKLAATRVSD
NVVREEDKLWTVKYAPTNLQQVCGNKGSVMKLKNWLANWENSKKNSFKHA
GKDGSGVFRAAMLYGPPGIGKTTAAHLVAQELGYDILEQNASDVRSKTLL
NAGVKNALDNMSVVGYFKHNLNGKHFVIIMDEVDGMSGGDRGGVGQLAQF
CRKTSTPLILICNERNLPKMRPFDRVCLDIQFRRPDANSIKSRLMTIAIR
EKFKLDPNVIDRLIQTTRGDIRQVINLLSTISTTTKTINHENINEISKAW
EKNIALKPFDIAHKMLDGQIYSDIGSRNFTLNDKIALYFDDFDFTPLMIQ
ENYLSTRPSVLKPGQSHLEAVAEAANCISLGDIVEKKIRSSEQLWSLLPL
HAVLSSVYPASKVAGHMAGRINFTAWLGQNSKSAKYYRLLQEIHYHTRLG
TSTDKIGLRLDYLPTFRKRLLDPFLKQGADAISSVIEVMDDYYLTKEDWD
SIMEFFVGPDVTTAIIKKIPATVKSGFTRKYNSMTHPVAIYRT

Ligand information

>8dr3 Chain J (length=18)

ccccccggcccccccggc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8dr3 Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): R434 F582 W638
• Binding residue (residue number reindexed from 1): R291 F439 W495

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003689 DNA clamp loader activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0000278 mitotic cell cycle
• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006271 DNA strand elongation involved in DNA replication
• GO:0006272 leading strand elongation
• GO:0006281 DNA repair
• GO:0006298 mismatch repair
• GO:0051301 cell division

Cellular Component

• GO:0005634 nucleus
• GO:0005663 DNA replication factor C complex

External links

• PDB: RCSB:8dr3, PDBe:8dr3, PDBj:8dr3
• PDBsum: 8dr3
• PubMed: 35939393
• UniProt: P38630|RFC1_YEAST Replication factor C subunit 1 (Gene Name=RFC1)