Structure of PDB 8dl8 Chain A Binding Site BS02

Receptor Information
>8dl8 Chain A (length=445) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVY
GLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVF
LHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAG
EDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLV
SMCVEYVLLWKVYQKTPALAVKAGCASQMAEPFRTFRDGWVSYYNQPVFL
AGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVA
FTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPPIISVSLLFAGV
IAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVI
LAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDA
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain8dl8 Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8dl8 Structural basis of ferroportin inhibition by minihepcidin PR73.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		C326 H507
Binding residue
(residue number reindexed from 1)		C267 H395
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005381 iron ion transmembrane transporter activity
GO:0005515 protein binding
GO:0015093 ferrous iron transmembrane transporter activity
GO:0017046 peptide hormone binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002260 lymphocyte homeostasis
GO:0003158 endothelium development
GO:0006366 transcription by RNA polymerase II
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006915 apoptotic process
GO:0034755 iron ion transmembrane transport
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048536 spleen development
GO:0051649 establishment of localization in cell
GO:0055085 transmembrane transport
GO:0060345 spleen trabecula formation
GO:0060586 multicellular organismal-level iron ion homeostasis
GO:1903988 iron ion export across plasma membrane
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016323 basolateral plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8dl8, PDBe:8dl8, PDBj:8dl8
PDBsum8dl8
PubMed36649314
UniProtQ9NP59|S40A1_HUMAN Ferroportin (Gene Name=SLC40A1)

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