Structure of PDB 8de7 Chain A Binding Site BS02

Receptor Information
>8de7 Chain A (length=263) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTVMKWKTVLAIFLLVVLYLIIGATVFKALEQPEEGLQKYRIIQEKIDFL
SMHTCVQTSELEDLVKQVVLAIRAGVNPSGHPSQESSMWDLSSSFFFAGT
VITTIGFGNVSPHTEGGRIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKG
IAKVEKMFVKWNVSQTKIRVTSTVLFILFGCLLFVALPALIFQHIEGWSA
LESIYFVVITLTTIGFGDFVAGGSEIEYLDYYKPIVWFWILVGLAYFAAV
LSMIGDWLRVISK
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain8de7 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8de7 Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Resolution3.27 Å
Binding residue
(original residue number in PDB)		T142 I143 G144 T251 I252 G253
Binding residue
(residue number reindexed from 1)		T104 I105 G106 T213 I214 G215
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8de7, PDBe:8de7, PDBj:8de7
PDBsum8de7
PubMed36841877
UniProtF1QAI2

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