Structure of PDB 8d40 Chain A Binding Site BS02

Receptor Information
>8d40 Chain A (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLF
DERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY
ITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANL
RYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGP
LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ
GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD
GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQ
AVDADSGENARLHYRLVDDFPFQIHNSSGWITVCAELDREEVEHYSFGVE
AVDHGSPPMSSSTSVSITVLDV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8d40 Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8d40 Crystal structure of human CELSR1 EC1-4
Resolution3.554 Å
Binding residue
(original residue number in PDB)		N112 H114 D144 D146 N150 D196
Binding residue
(residue number reindexed from 1)		N109 H111 D141 D143 N147 D193
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d40, PDBe:8d40, PDBj:8d40
PDBsum8d40
PubMed
UniProtQ9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)

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