Structure of PDB 8d2n Chain A Binding Site BS02

Receptor Information
>8d2n Chain A (length=1105) Species: 351607 (Acidothermus cellulolyticus 11B) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVPVTWRLGVDVGERSIGLAAVSYEEDKPKEILAAVSWIHDGGVGDERS
GASRLALRGMARRARRLRRFRRARLRDLDMLLSELGWTPLPDKNVSPVDA
WLARKRLAEEYVVDETERRRLLGYAVSHMARHRGWRNPWTTIKDLKNLPQ
PSDSWERTRESLEARYSVSLEPGTVGQWAGYLLQRAPGIRLNPTQQSLSN
ATAFETRLRQEDVLWELRCIADVQGLPEDVVSNVIDAVFCQKRPSVPAER
IGRDPLDPSQLRASRACLEFQEYRIVAAVANLRIRDGSGSRPLSLEERNA
VIEALLAQTERSLTWSDIALEILKLPNESDLTSVPEEDGPSSLAYSQFAP
FDETSARIAEFIAKNRRKIPTFAQWWQEQDRTSRSDLVAALADNSIAGLL
VHLPDAELEALEGLALPSGRVAYSRLTLSGLTRVMRDDGVDVHNARKTCF
GVDDNWRPPLPALHEATGHPVVDRNLAILRKFLSSATMRWGPPQSIVVEL
ARGASESRERQAEEEAARRAHRKANDRIRAELRASGLSDPSPADLVRARL
LELYDCHCMYCGAPISWENSELDHIVPRTDGGSNRHENLAITCGACNKEK
GRRPFASWAETSNRVQLRDVIDRVQKLKYSGNMYWTRDEFSRYKKSVVAR
LKRRTSDPEVIQSIESTGYAAVALRDRLLSYGEKNGVAQVAVFRGGVTAE
ARRWLDISIERLFSRVAIFAQSTSTKRLDRRHHAVDAVVLTTLTPGVAKT
LADARSRRVSASTEEPQSPAYRQWKESCSGLGDLLISTAARDSIAVAAPL
RLRPTGALHEETLRAFSEHTVGAAWKGAELRRIVEPEVYAAFLALTDPGG
RFLKVSPSEDVLPADENRHIVLSDRVLGPRDRVKLFPDDRGSIRVRGGAA
YIASFHHARVFRWGSSHSPSFALLRVSLADLAVAGLLRDGVDVFTAELPP
WTPAWRYASIALVKAVESGDAKQVGWLVPGDELDFGPEGVTTAAGDLSMF
LKYFPERHWVVTGFEDDKRINLKPAFLSAEQAEVLRTERSDRPDTLTEAG
EILAQFFPRCWRATVAKVLCHPGLTVIRRTALGQPRWRRGHLPYSWRPWS
ADPWS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d2n Coupled catalytic states and the role of metal coordination in Cas9
Resolution2.88 Å
Binding residue
(original residue number in PDB)		R55 W141 N143 P144 W145 Q201 R219 V258 I263 G264 R274 R437 T684 Y686 V689 E839 E840 T841 R843 D1025 R1048 R1088 R1091 T1093
Binding residue
(residue number reindexed from 1)		R49 W135 N137 P138 W139 Q195 R207 V246 I251 G252 R262 R420 T667 Y669 V672 E810 E811 T812 R814 D996 R1019 R1059 R1062 T1064
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8d2n, PDBe:8d2n, PDBj:8d2n
PDBsum8d2n
PubMed38348449
UniProtA0LWB3

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