Structure of PDB 8d2k Chain A Binding Site BS02

Receptor Information
>8d2k Chain A (length=1105) Species: 351607 (Acidothermus cellulolyticus 11B) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVPVTWRLGVDVGERSIGLAAVSYEEDKPKEILAAVSWIHDGGVGDERS
GASRLALRGMARRARRLRRFRRARLRDLDMLLSELGWTPLPDKNVSPVDA
WLARKRLAEEYVVDETERRRLLGYAVSHMARHRGWRNPWTTIKDLKNLPQ
PSDSWERTRESLEARYSVSLEPGTVGQWAGYLLQRAPGIRLNPTQQSLSN
ATAFETRLRQEDVLWELRCIADVQGLPEDVVSNVIDAVFCQKRPSVPAER
IGRDPLDPSQLRASRACLEFQEYRIVAAVANLRIRDGSGSRPLSLEERNA
VIEALLAQTERSLTWSDIALEILKLPNESDLTSVPEEDGPSSLAYSQFAP
FDETSARIAEFIAKNRRKIPTFAQWWQEQDRTSRSDLVAALADNSIAGLL
VHLPDAELEALEGLALPSGRVAYSRLTLSGLTRVMRDDGVDVHNARKTCF
GVDDNWRPPLPALHEATGHPVVDRNLAILRKFLSSATMRWGPPQSIVVEL
ARGASESRERQAEEEAARRAHRKANDRIRAELRASGLSDPSPADLVRARL
LELYDCHCMYCGAPISWENSELDHIVPRTDGGSNRHENLAITCGACNKEK
GRRPFASWAETSNRVQLRDVIDRVQKLKYSGNMYWTRDEFSRYKKSVVAR
LKRRTSDPEVIQSIESTGYAAVALRDRLLSYGEKNGVAQVAVFRGGVTAE
ARRWLDISIERLFSRVAIFAQSTSTKRLDRRHHAVDAVVLTTLTPGVAKT
LADARSRRVSASTEEPQSPAYRQWKESCSGLGDLLISTAARDSIAVAAPL
RLRPTGALHEETLRAFSEHTVGAAWKGAELRRIVEPEVYAAFLALTDPGG
RFLKVSPSEDVLPADENRHIVLSDRVLGPRDRVKLFPDDRGSIRVRGGAA
YIASFHHARVFRWGSSHSPSFALLRVSLADLAVAGLLRDGVDVFTAELPP
WTPAWRYASIALVKAVESGDAKQVGWLVPGDELDFGPEGVTTAAGDLSMF
LKYFPERHWVVTGFEDDKRINLKPAFLSAEQAEVLRTERSDRPDTLTEAG
EILAQFFPRCWRATVAKVLCHPGLTVIRRTALGQPRWRRGHLPYSWRPWS
ADPWS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8d2k Coupled catalytic states and the role of metal coordination in Cas9
Resolution2.43 Å
Binding residue
(original residue number in PDB)		R55 T596 N614 G618 R619 E839 E840 T841 R843 G1024 D1025 R1048 R1088 R1091 T1093 K1096
Binding residue
(residue number reindexed from 1)		R49 T579 N597 G601 R602 E810 E811 T812 R814 G995 D996 R1019 R1059 R1062 T1064 K1067
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8d2k, PDBe:8d2k, PDBj:8d2k
PDBsum8d2k
PubMed38348449
UniProtA0LWB3

[Back to BioLiP]