Structure of PDB 8d16 Chain A Binding Site BS02

Receptor Information

>8d16 Chain A (length=371) Species: 9031 (Gallus gallus)

TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYV
GDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTL
LTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLD
SGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTA
EREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNER
FRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTT
MYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQ
MWITKQEYDEAGPSIVHRKCF

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8d16 Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8d16 Bending forces and nucleotide state jointly regulate F-actin structure.
• Resolution: 3.71 Å
• Binding residue (original residue number in PDB): Q137 D154
• Binding residue (residue number reindexed from 1): Q133 D150
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0030240 skeletal muscle thin filament assembly
• GO:0048741 skeletal muscle fiber development

Cellular Component

• GO:0001725 stress fiber
• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005865 striated muscle thin filament
• GO:0005884 actin filament

External links

• PDB: RCSB:8d16, PDBe:8d16, PDBj:8d16
• PDBsum: 8d16
• PubMed: 36289330
• UniProt: P68139|ACTS_CHICK Actin, alpha skeletal muscle (Gene Name=ACTA1)